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Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
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RAN-S100A10-EGFR axis facilitates papillary thyroid cancer metastasis by PI3K/AKT signaling
Wenbin Song1, Zhaoyi Liu1, Cangchang Shi1
1Department of General Surgery, Tianjin Medical University General Hospital, Tianjin Key Laboratory of Precise Vascular Reconstruction and Organ Function Repair, Tianjin General Surgery Institute, Tianjin, China.
Cell Death & Disease
|April 16, 2026
Summary
Papillary thyroid carcinoma (PTC) progression is linked to S100A10, a protein promoting metastasis and activating PI3K/AKT signaling. Targeting S100A10 and RAN offers potential new therapies for thyroid cancer.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Thyroid cancer incidence, particularly papillary thyroid carcinoma (PTC), is rising globally.
- S100A10 is implicated as an oncogene in various cancers, but its role in PTC is unclear.
Purpose of the Study:
- To investigate the function and mechanism of S100A10 in papillary thyroid carcinoma progression.
- To identify S100A10 as a potential biomarker for PTC metastasis and prognosis.
Main Methods:
- Analysis of single-cell RNA sequencing data to identify differentially expressed genes in PTC.
- Validation of S100A10 expression using RT-qPCR, western blot, and immunofluorescence.
- In vitro and in vivo assays to assess the impact of S100A10 on cell invasion and epithelial-mesenchymal transition (EMT).
Main Results:
- S100A10 expression is elevated in PTC tissues and cells, correlating with poor prognosis and metastasis.
- S100A10 promotes PTC cell invasion and EMT by activating the PI3K/AKT signaling pathway.
- A regulatory axis involving RAN, S100A10, and EGFR was identified.
Conclusions:
- S100A10 plays a critical role in PTC progression and metastasis.
- The RAN-S100A10-EGFR axis and PI3K/AKT signaling are key mechanisms in PTC.
- S100A10 and RAN represent promising therapeutic targets for papillary thyroid carcinoma.
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