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FcγR-driven chimeric receptor T cells in cancer therapy: a novel frontier in antibody-guided immunotherapy

Hany E Marei1, Giacomo Pozzoli2,3, Sara Caratelli4

  • 1Department of Cytology and Histology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35116, Egypt. hanymarei@mans.edu.eg.

Cancer Cell International
|April 17, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Adoptive cellular therapy (ACT)Antibody-dependent cellular cytotoxicity (ADCC)CD16a (FcγRIIIa)CD32a (FcγRIIa)CD64a (FcγRI)CRISPR/Cas9 in cell therapyCheckpoint inhibitorsChimeric receptor (CR) T cellsClinical translation of engineered T cellsEngineered T cellsFc gamma receptors (FcγRs)FcγR-CRT cells therapyGene editing for immunotherapyImmunotherapy for solid tumorsMonoclonal antibody-based immunotherapyPersonalized cancer therapySolid tumorsSynthetic immunoreceptorsTumor microenvironment (TME)

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