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Updated: Jun 21, 2026
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Periodontitis Is Associated With Serum Prostate Specific Antigen Concentrations in Chinese Male
Yifei Long1, Qi Liu1, Pengfei Shen2
1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Objective:
This study aimed to clarify the association between periodontitis and prostate-specific antigen and to guide the early prostate-specific antigen screening of periodontitis patients.
Materials And Methods:
1409 participants who visited West China Hospital of Sichuan University during 2021 and 2022 were included. Measurements were taken for blood pressure, fasting blood glucose, total cholesterol, triglycerides, C-reactive protein, carcinoembryonic antigen, and prostate-specific antigen. Participants went through periodontal examinations and were grouped into non-periodontitis individuals, mild periodontitis, moderate periodontitis, and severe periodontitis. Logistic regression was used to explore the potential associations.
Results:
Patients with severe periodontitis had significantly higher serum prostate-specific antigen compared to non-periodontitis individuals. No significant association between periodontitis and prostate-specific antigen was found in participants aged 20-40. In patients aged 41-80, regression models showed a significant association between elevated prostate-specific antigen and severe periodontitis, which was not significant in patients with mild and moderate periodontitis.
Conclusion:
In Chinese men aged 20-80 years, serum prostate-specific antigen was significantly higher in patients with severe periodontitis than in non-periodontitis patients. Severe periodontitis was significantly associated with elevated PSA levels among elder patients.
