Protonation-Triggered Fluorescence Switching in COF Membranes for the Selective and Rapid Detection of New
Yan Luo1, Lejie Liu1, Qingtong Wu1
1Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, Shaanxi Provincial Key Laboratory of New Concept Sensors and Molecular Materials, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, P. R. China.
Abstract:
New psychoactive substances (NPS) typically exhibit low saturated vapor concentrations and are susceptible to interference such as water vapor and carbon dioxide, making the realization of high-performance gas-phase detection a challenge in both scientific research and public safety. Herein, we presented a self-standing covalent organic framework (COF) membrane formed between 1,3,5-tris-(4-aminophenyl)triazine (TTPA) and 4,4',4''-nitrilotribenzaldehyde (TFPA), TTPA-TFPA COF, which was fabricated via a two-step synthesis involving interface-confined polymerization followed by post-processing. The sensor used the ozone-treated COF membrane as the sensing layer exhibited rapid, highly selective, and visually observable fluorescence response toward the NPS simulant (S)-N,α-dimethylbenzylamine (DMBA), achieving a fast response time of less than 1 min and an ultra-low detection limit of 2.1 ppb. Moreover, the sensor successfully discriminates seven structurally analogous NPS reference standards through kinetic response profiling. The infrared and XPS spectra, along with theoretical calculations, further reveal the sensing mechanism is driven by hydrogen bond interaction between the ozone-treated COF membrane and the DMBA. These findings offer valuable insights for developing portable, real-time chemical monitoring devices, providing an innovative solution for on-site trace-level NPS detection. This holds promising potential for addressing serious threats to human health, family harmony, and social stability.
