Teaching design of a multi-dimensional aging experiment using the Caenorhabditis elegans model

Area of Science:

• Life Sciences Education
• Model Organism Research
• Undergraduate Pedagogy

Background:

• Caenorhabditis elegans (C. elegans) is a vital model organism in life sciences due to its ease of cultivation and short life cycle.
• C. elegans is extensively utilized in research areas such as developmental biology, aging, genetics, and stress response studies.
• Enhancing undergraduate research literacy and experimental skills is crucial for scientific training.

Purpose of the Study:

• To design and implement an experimental teaching system using C. elegans for undergraduate life science courses.
• To integrate progressive learning and inquiry-based teaching principles into the curriculum.
• To improve students' research literacy and practical experimental competence.

Main Methods:

• Developed a four-module experimental system focusing on C. elegans: morphological observation, behavioral analysis, microscopic structure identification, and intestinal barrier assessment.
• Incorporated advanced techniques like microscopic imaging and quantitative behavioral analysis.
• Emphasized scientific communication skills development alongside experimental techniques.

Main Results:

• The C. elegans teaching system demonstrated a short experimental cycle, low cost, and high safety.
• Results were clear and intuitive, effectively stimulating student interest in scientific research.
• The system fostered the development of scientific thinking and improved experimental competence.

Conclusions:

• The C. elegans-centered experimental system is a valuable tool for reforming undergraduate life science education.
• This approach effectively enhances students' practical skills and scientific inquiry abilities.
• The study highlights the broader applicability of genetic model organisms in educational settings.