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FungiNetDB: a uniform (pre-)processing platform for fungal expression data.

Sascha Schäuble1, Daniela Albrecht-Eckardt2, Gianni Panagiotou1,3

  • 1Department of Microbiome Dynamics, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute (Leibniz-HKI), 07745 Jena, Germany.

Microlife
|April 17, 2026
PubMed
Summary
This summary is machine-generated.

FungiNetDB offers a comprehensive resource for fungal transcriptomics, integrating 139 datasets. This platform aids researchers in analyzing fungal gene expression and identifying virulence factors without needing programming skills.

Keywords:
databasefungal pathogensgene expressionwarehouse

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Area of Science:

  • Mycology and Bioinformatics
  • Genomics and Transcriptomics
  • Computational Biology

Background:

  • Fungal pathogens pose increasing threats to human health and economies.
  • High-throughput technologies provide deep molecular insights into fungal mechanisms.
  • Existing fungal gene expression data is often siloed and difficult to compare across studies.

Purpose of the Study:

  • To develop a centralized, accessible platform for fungal transcriptomics data analysis.
  • To facilitate cross-project comparisons and identification of fungal biomarkers.
  • To overcome challenges related to data preprocessing and technological biases.

Main Methods:

  • Compilation of 139 fungal pathogenicity datasets.
  • Statistical analysis of over 2000 pairwise gene expression comparisons.
  • Development of a user-friendly web platform (FungiNetDB) for data exploration.

Main Results:

  • FungiNetDB provides a comprehensive fungal transcriptomics resource.
  • The platform enables exploration without programming knowledge.
  • Customizable filtering, cross-project comparisons, and data downloads are supported.

Conclusions:

  • FungiNetDB democratizes access to fungal transcriptomics data.
  • The resource supports multifaceted analysis of fungal gene expression.
  • It aids in identifying essential fungal components for survival and virulence.