Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Decision Making01:20

Decision Making

1.3K
Decision-making is a fundamental cognitive process that involves evaluating alternatives and selecting among them. This process can range from simple choices, such as deciding what to wear, to complex decisions, like choosing a major in college or a career path. The complexity of the decision often dictates the approach we use, which can be broadly categorized into two types: automatic and controlled decision-making.
Automatic decision-making is fast, intuitive, and relies on gut feelings...
1.3K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

8.0K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
8.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-speed whole-brain imaging in Drosophila.

Nature communications·2026
Same author

Neural circuit models for evidence accumulation through choice-selective sequences.

Nature communications·2026
Same author

Working memory expands shared task representations in cortex.

bioRxiv : the preprint server for biology·2025
Same author

FixGrower: An efficient and robust curriculum for shaping fixation behavior in rodents.

bioRxiv : the preprint server for biology·2025
Same author

Transitions in dynamical regime and neural mode during perceptual decisions.

Nature·2025
Same author

Connectomic reconstruction from hippocampal CA3 reveals spatially graded mossy fiber inputs and selective feedforward inhibition to pyramidal cells.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Apr 18, 2026

Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy
10:35

Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy

Published on: June 13, 2017

32.4K

Single-Cell Perturbations Reveal Selective Modulation of Causal Connectivity During Decision-Making.

Mark Ioffe1, Stephan Y Thiberge1, Carlos Brody1,2

  • 1Princeton Neuroscience Institute, Princeton, NJ, USA.

Biorxiv : the Preprint Server for Biology
|April 17, 2026
PubMed
Summary
This summary is machine-generated.

Neural circuit connectivity dynamically changes during decision-making tasks. Researchers found that cortical connectivity in the retrosplenial cortex is modulated during the cue and decision phases of navigation tasks, suggesting a flexible circuit mechanism.

More Related Videos

Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance
13:20

Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance

Published on: December 5, 2025

1.4K
An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents
07:42

An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents

Published on: August 2, 2018

14.6K

Related Experiment Videos

Last Updated: Apr 18, 2026

Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy
10:35

Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy

Published on: June 13, 2017

32.4K
Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance
13:20

Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance

Published on: December 5, 2025

1.4K
An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents
07:42

An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents

Published on: August 2, 2018

14.6K

Area of Science:

  • Neuroscience
  • Systems Neuroscience
  • Computational Neuroscience

Background:

  • Decision-making involves sequential computations like evidence accumulation and motor output.
  • Understanding how fixed neural circuits support these dynamic phases is a key challenge.
  • Cortical connectivity modulation is a potential, yet untested, mechanism.

Purpose of the Study:

  • To investigate whether neuronal connectivity in the retrosplenial cortex changes across different phases of a navigation-based decision-making task.
  • To determine if these connectivity changes are specific to task engagement and behavioral epochs.

Main Methods:

  • Utilized an all-optical method to probe causal connectivity.
  • Focused on excitatory neurons in layer 2/3 of the mouse retrosplenial cortex.
  • Compared neuronal connectivity during task performance versus a no-task baseline.

Main Results:

  • Cortical connectivity during the task differed significantly from the no-task condition.
  • Connectivity differences were most pronounced during the cue/decision phase.
  • These task-related connectivity modulations diminished in later stages of the task.

Conclusions:

  • Fast modulation of neuronal connectivity is a key mechanism supporting dynamic computations in neural circuits.
  • The retrosplenial cortex exhibits experience-dependent connectivity changes during decision-making.
  • This highlights the adaptability of neural circuits beyond fixed anatomical connections.