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Updated: Apr 18, 2026

Visualizing Clathrin-mediated Endocytosis of G Protein-coupled Receptors at Single-event Resolution via TIRF Microscopy
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Visualizing Clathrin-mediated Endocytosis of G Protein-coupled Receptors at Single-event Resolution via TIRF Microscopy

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PROTAC internalization and target degradation require clathrin-mediated endocytosis.

Hao-Yang Liu1, Zhengyu Wang2, Rahul Sharma1

  • 1Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, United States.

Biorxiv : the Preprint Server for Biology
|April 17, 2026
PubMed
Summary

Proteolysis-targeting chimeras (PROTACs) enter cells via clathrin-mediated endocytosis, not passive diffusion. This pathway is essential for PROTAC function and targeted protein degradation.

Keywords:
CD36Proteolysis Targeting Chimerascellular uptakeclathrin-mediated endocytosisprotein degradation

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