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Related Experiment Video

Updated: Apr 18, 2026

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Sensitization strategy for sonodynamic therapy.

Sinong Li1, Ziyi Yang1, Ying Zhang1

  • 1Department of Ultrasound, the First Hospital of China Medical University. China Medical University, No.155, Nanjing North Road, Shenyang 110001, China.

Theranostics
|April 17, 2026
PubMed
Summary
This summary is machine-generated.

Sonodynamic therapy (SDT) shows promise for deep tumor treatment but faces challenges. This review outlines synergistic strategies in material design, microenvironment regulation, and immune remodeling to enhance SDT efficacy for cancer therapy.

Keywords:
piezoelectric sonodynamic therapysonodynamic immunotherapysonodynamic therapysonosensitizers

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Area of Science:

  • Biomedical Engineering
  • Oncology
  • Materials Science

Background:

  • Sonodynamic therapy (SDT) offers precise, deep-tissue tumor treatment.
  • Clinical translation is hindered by low sonosensitizer efficiency, tumor microenvironment (TME) suppression, and weak antitumor immunity.

Purpose of the Study:

  • To systematically review multifaceted sensitization strategies for enhancing SDT.
  • To establish a comprehensive synergistic enhancement framework for SDT.

Main Methods:

  • Review of advanced sonosensitizer engineering (defect engineering, heterostructures, piezoelectric materials) for enhanced reactive oxygen species (ROS) generation.
  • Analysis of TME modulation strategies (hypoxia alleviation, metabolic reprogramming, targeted delivery) to improve selectivity and reduce ROS scavenging.
  • Examination of SDT integration with other therapies (chemodynamic, photo-, immunotherapy, ferroptosis/cuproptosis) for synergistic antitumor effects.

Main Results:

  • Advanced material design significantly boosts ROS generation via band structure modulation and mechano-electro-chemical coupling.
  • TME-targeted strategies effectively mitigate ROS scavenging and enhance tumor selectivity.
  • Multimodal SDT combinations demonstrate potential in inducing immunogenic cell death and reversing immunosuppression.

Conclusions:

  • A systematic framework integrating material design, TME regulation, and immune remodeling is crucial for SDT advancement.
  • Multimodal, responsive, and biohybrid platforms are paving the way for intelligent, precise cancer treatment.
  • SDT holds significant translational potential for treating deep-seated and drug-resistant solid tumors.