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Tight junctions in choroid plexus papillomas.

S Wakai, M Matsutani, H Mizutani

Acta Neuropathologica

|February 15, 1979

Summary

Electron microscopy revealed that choroid plexus papilloma (CPP) shares tight junction characteristics with normal choroid plexus (CP). This suggests a blood-cerebrospinal fluid barrier exists in both conditions.

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Area of Science:

Neuroscience
Pathology
Cell Biology

Background:

Choroid plexus (CP) forms the blood-cerebrospinal fluid (CSF) barrier.
The barrier function of choroid plexus papilloma (CPP) is not well understood.

Purpose of the Study:

To investigate the ultrastructural characteristics of CPP.
To compare the tight junctions in CPP with normal CP to assess barrier function.

Main Methods:

Electron microscopy was used to examine four surgical samples of CPP.
Normal CP from mice and chicks served as controls.

Main Results:

Apical tight junctions in CPP showed fusion of the two outer leaflets of the adjacent cytoplasmic membrane, similar to normal CP.
This ultrastructural similarity indicates comparable barrier mechanisms.

Conclusions:

The findings suggest that a blood-cerebrospinal fluid barrier is present in choroid plexus papilloma.
CPP may maintain barrier properties similar to normal choroid plexus, impacting its biological behavior and treatment.

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