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Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

5
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
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Updated: Apr 18, 2026

An Ex Vivo Tissue Culture Model for Fibrovascular Complications in Proliferative Diabetic Retinopathy
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Survival Rates After Pars Plana Vitrectomy for Proliferative Diabetic Retinopathy.

Megan E Chung1, Carolyn K Pan1, Stephen J Smith1

  • 1Byers Eye Institute, Horngren Family Vitreoretinal Center, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, USA.

Journal of Vitreoretinal Diseases
|April 17, 2026
PubMed
Summary
This summary is machine-generated.

Long-term survival for proliferative diabetic retinopathy (PDR) patients after pars plana vitrectomy (PPV) remains stable. Prompt cardiovascular and renal optimization alongside multidisciplinary care is crucial for these patients.

Keywords:
diabetespars plana vitrectomyproliferative diabetic retinopathysurvivaltractional retinal detachmentvitreous hemorrhage

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Area of Science:

  • Ophthalmology
  • Diabetology
  • Public Health

Background:

  • Proliferative diabetic retinopathy (PDR) is a severe complication of diabetes mellitus.
  • Pars plana vitrectomy (PPV) is a surgical intervention for PDR complications like vitreous hemorrhage and tractional retinal detachment.
  • Updated survival data for PDR patients undergoing PPV is essential.

Purpose of the Study:

  • To provide current survival data for patients with PDR who underwent PPV.
  • To identify prognostic factors influencing survival in PDR patients post-PPV.
  • To compare survival rates between PDR patients with and without a history of PPV.

Main Methods:

  • Utilized an aggregated electronic health records research network.
  • Included patients diagnosed with PDR who underwent PPV (2009-2019) and a control group without PPV.
  • Employed propensity score matching for demographic and clinical variables; Kaplan-Meier method for survival analysis.

Main Results:

  • Overall 3-, 5-, and 10-year survival rates post-PPV were 89.2%, 80.9%, and 52.8%.
  • Patients with PDR and a history of PPV had significantly lower survival rates at 3, 5, and 10 years compared to those without PPV.
  • Survival rates were comparable between PPV for vitreous hemorrhage versus tractional retinal detachment.

Conclusions:

  • Long-term survival for PDR patients after PPV has remained consistent over two decades.
  • The findings underscore the critical need for comprehensive care, including cardiovascular and renal health management.
  • Multidisciplinary evaluation is vital for optimizing outcomes in PDR patients.