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Time-Driven Activity-Based Costing Methodology for Cost Savings in the EMOTE-TNK Study
Saptarshi Ghosh1, Isabelle Delos Reyes2, Carlos Perez Vega3,4
1Department of Physical Medicine and Rehabilitation, Mayo Clinic, Jacksonville, FL.
Mayo Clinic Proceedings. Innovations, Quality & Outcomes
|April 17, 2026
Summary
Early mobilization for acute ischemic stroke patients receiving tenecteplase (TNK) significantly reduces hospitalization costs by $1250 per patient. This approach shortens hospital stays, offering substantial financial savings and improved resource utilization.
Area of Science:
- Neurology
- Health Economics
- Rehabilitation Medicine
Background:
- Acute ischemic stroke requires timely intervention.
- Tenecteplase (TNK) is a common thrombolytic agent.
- Early mobilization is increasingly recognized for its benefits in stroke recovery.
Purpose of the Study:
- To calculate the financial savings associated with early mobilization in acute ischemic stroke patients treated with tenecteplase (TNK).
- To compare the costs of early mobilization versus conventional mobilization strategies.
Main Methods:
- Utilized Time-Driven Activity-Based Costing methodology.
- Compared 180 patients undergoing early mobilization (13-24 hours post-thrombolysis) with those receiving conventional mobilization (≥24 hours post-thrombolysis).
- Data collected from February 2021 to March 2024.
Main Results:
- Early mobilization reduced average hospitalization duration by 0.5 days.
- Estimated cost savings of $1250 per patient.
- Total savings for 180 patients amounted to $225,000, with a reduction of 90 hospital days.
Conclusions:
- Early mobilization in acute ischemic stroke patients receiving TNK is associated with up to a 25% cost reduction.
- Suggests further research into the broader impacts of early mobilization on discharge planning and overall quality of care.
