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Letrozole Reduces Ovulatory Responsiveness in In Vitro-Grown Mouse Follicles.

Tatsuya Kobayashi1, Hiroshi Ishikawa2, Hirokazu Tanaka3

  • 1Research Promotion Unit, School of Medical Sciences Fujita Health University Tokyo Japan.

Reproductive Medicine and Biology
|April 17, 2026
PubMed
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This summary is machine-generated.

Continuous letrozole exposure in mouse follicles reduced ovulation rates and key gene expression, suggesting impaired ovulatory competence due to estrogen deficiency.

Area of Science:

  • Reproductive Biology
  • Endocrinology
  • In Vitro Fertilization Research

Background:

  • Aromatase inhibition is crucial for ovulation induction.
  • Understanding the impact of continuous aromatase inhibition on follicular development is essential.

Purpose of the Study:

  • To investigate if continuous aromatase inhibition with letrozole affects peri-ovulatory responsiveness in in vitro-grown mouse follicles.

Main Methods:

  • Mouse follicles were cultured with letrozole or vehicle.
  • Follicle growth, ovulation rates, and gene expression (Lhcgr, Ptgs2, Runx1, Foxo1) were analyzed.
  • The effect of estradiol supplementation was examined.

Main Results:

  • Letrozole reduced ovulation rates dose-dependently without affecting follicle growth.
Keywords:
breast cancer; letrozoleluteinizing hormone/chorionic gonadotropin receptorovulation

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  • mRNA levels of Lhcgr, Runx1, and Ptgs2 decreased with letrozole treatment.
  • Estradiol restored gene expression and partially rescued ovulatory capacity.

    • Conclusions:

    • Continuous letrozole exposure impairs ovulatory responsiveness in mouse follicles.
    • Estrogen deficiency from letrozole likely reduces Lhcgr expression and peri-ovulatory competence.
    • Prolonged aromatase inhibition may negatively impact follicular development for ovulation.