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Risk factors and prediction models for bronchitis obliterans after severe Mycoplasma pneumoniae pneumonia with

Fang Cheng1, Ruixue Sun2, Yingmian Zhao3

  • 1Fang Cheng, Department of Pediatrics, Xingtai People's Hospital, Xingtai Emergency Center, Xingtai 054000, Hebei, China.

Pakistan Journal of Medical Sciences
|April 17, 2026
PubMed

Insights

Elevated lactate dehydrogenase is a risk factor for bronchitis obliterans in children with severe Mycoplasma pneumoniae pneumonia. Immunoglobulin A levels may protect against this condition, aiding in predictive model development.

Area of Science:

  • Pediatric Pulmonology
  • Infectious Diseases
  • Clinical Diagnostics

Background:

  • Severe Mycoplasma pneumoniae pneumonia (SMPP) can lead to complications like bronchitis obliterans in children.
  • Identifying risk factors for bronchitis obliterans is crucial for early intervention and improved outcomes.

Purpose of the Study:

  • To investigate risk factors associated with bronchitis obliterans in children diagnosed with SMPP.
  • To develop a predictive nomogram for identifying children at risk of developing bronchitis obliterans.

Main Methods:

  • A retrospective analysis of clinical data from 464 children with SMPP was conducted.
  • Children were categorized into bronchitis obliterans and simple pneumonia (PB) groups.
  • Statistical analysis, including chi-square and Mann-Whitney U tests, was performed using SPSS 26.0.

Main Results:

  • Lactate dehydrogenase (LDH) levels were significantly higher in children with bronchitis obliterans compared to those with PB.
  • Immunoglobulin A (IgA) levels were significantly lower in children with bronchitis obliterans.
  • Higher LDH was identified as an independent risk factor, while higher IgA was an independent protective factor.

Conclusions:

  • Elevated LDH is a significant independent risk factor for developing bronchitis obliterans in children with SMPP.
  • LDH and IgA demonstrate potential for a nomogram-based prediction model for bronchitis obliterans risk.
  • The findings support the development of targeted diagnostic and management strategies for SMPP complications.
Abstract

Keywords:
Bronchiolitis obliteransBronchitis obliteransElectronic bronchoscopyNomogram modelPlastic bronchitisPredictionSevere Mycoplasma pneumoniae pneumonia

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