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Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

181
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
181
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

226
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
226
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

237
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
237
Allergic Reactions02:06

Allergic Reactions

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Overview
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Precipitation Gravimetry01:03

Precipitation Gravimetry

16.4K
Precipitation gravimetry is based on converting an analyte into a sparingly soluble precipitate, which is separated by filtration and weighed. An ideal precipitate should be pure, insoluble, of known composition, and easily filtered from the reaction mixture.
In determining nickel by gravimetric analysis, a precipitant of ethanolic dimethylglyoxime is added to a hot nickel salt solution. This is quickly followed by the dropwise addition of dilute ammonia solution until precipitation occurs. A...
16.4K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Related Experiment Video

Updated: Apr 18, 2026

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
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Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

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Systemic Nickel Allergy Syndrome.

Allison Freeman1, Ashleigh Letterman1, Jeffrey Boos2

  • 1Alice L. Walton School of Medicine, Bentonville, Ark.

American Journal of Medicine Open
|April 17, 2026
PubMed
Summary
This summary is machine-generated.

Systemic nickel allergy syndrome (SNAS) can cause various symptoms. A low-nickel diet effectively resolved dermatitis, fibromyalgia, and IBS in a patient with SNAS.

Keywords:
AllergyDermatitisDietFibromyalgiaIrritable bowel syndromeNickel

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Area of Science:

  • Allergy and Immunology
  • Dermatology
  • Gastroenterology

Background:

  • Systemic nickel allergy syndrome (SNAS) involves cutaneous and extracutaneous symptoms after nickel exposure.
  • Nickel sensitization often occurs via skin contact, leading to reactions from ingested nickel.
  • Symptoms include dermatitis, gastrointestinal issues, and neurological problems.

Purpose of the Study:

  • To report a case of SNAS with resolution of symptoms after dietary intervention.
  • To highlight the efficacy of a low-nickel diet in managing SNAS.

Main Methods:

  • A patient with a history of nickel allergy and symptoms of dermatitis, fibromyalgia, and irritable bowel syndrome was treated with a low-nickel diet.
  • Symptom resolution was monitored over one month.

Main Results:

  • The patient experienced complete resolution of hand dermatitis, chronic pain (fibromyalgia), and chronic diarrhea (irritable bowel syndrome) within one month of adhering to a low-nickel diet.
  • This outcome suggests a strong link between dietary nickel intake and SNAS symptoms.

Conclusions:

  • A low-nickel diet can be an effective treatment for Systemic Nickel Allergy Syndrome.
  • Dietary modification should be considered for patients presenting with a combination of allergic contact dermatitis and unexplained systemic symptoms.