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Failure of a Single-Session Intralesional Triamcinolone Injection to Prevent a Stricture After ≥90% Circumferential
Taiji Yoshimoto1, Ayaka Nakanishi1, Hiroshi Takihara2,3
1Department of Gastroenterology, Tachikawa Sogo Hospital, Tachikawa, JPN.
Cureus
|April 17, 2026
Summary
Even with triamcinolone acetonide (TAC) injections, near-circumferential colorectal endoscopic submucosal dissection (ESD) can still lead to rectal strictures. Further research is needed for better prevention strategies in high-risk cases.
Area of Science:
- Gastroenterology
- Endoscopy
- Surgical Oncology
Background:
- Near-circumferential colorectal endoscopic submucosal dissection (ESD) has a high risk of postoperative strictures (11-43%), necessitating interventions like balloon dilation.
- Intralesional triamcinolone acetonide (TAC) injection is used for esophageal ESD stricture prevention, but its efficacy in colorectal ESD is not well-established.
Keywords:
circumferential defectcolorectal endoscopic submucosal dissectionpostoperative rectal strictureprophylactic intralesional steroid injectionsteroid prophylaxis
