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Essential Minerals for Bone Health

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

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Updated: Apr 20, 2026

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Published on: July 10, 2014

Bibliometric Analysis on Enamel Remineralization Agents.

Sangaragomathy A M¹, Shruthi Eshwar¹, Aarya N Bharadwaj¹

¹Public Health Dentistry, KLE Society's Institute of Dental Sciences, Bengaluru, IND.

|April 17, 2026

Summary

Research on enamel remineralization agents shows steady growth and diversification. Fluoride and CPP-ACP remain key, with emerging biomimetic agents like nanohydroxyapatite driving new research waves.

Keywords:

bibliometric analysis bioactive glass biomimetic agents cpp-acp enamel remineralization fluoride nanohydroxyapatite preventive dentistry

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Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

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Published on: March 31, 2021

Area of Science:

Biomaterials Science
Dental Research
Preventive Dentistry

Background:

Dental caries is a significant global oral health issue affecting billions.
Modern dentistry prioritizes preventive and minimally invasive strategies for enamel remineralization.
Understanding trends in enamel remineralization research is crucial for advancing dental care.

Purpose of the Study:

To conduct a bibliometric analysis of enamel remineralization agents.
To identify publication trends, research activity waves, and emerging agent types.
To map the landscape of enamel remineralization research from 2015-2025.

Main Methods:

Comprehensive literature search in PubMed for enamel remineralization agents (2015-2025).
Inclusion of clinical trials, RCTs, systematic reviews, and meta-analyses.
Bibliometric analysis using RStudio (Biblioshiny package) for trends, impact, and networks.

Main Results:

153 publications from 68 sources, contributed by 700 authors, with 10.65% annual growth.
Two research waves identified: fluoride and CPP-ACP initially, followed by biomimetic agents.
Fluoride and CPP-ACP remain foundational, while nanohydroxyapatite, bioactive glass, peptides, and natural products show promise.

Conclusions:

Enamel remineralization research is characterized by steady growth, global collaboration, and diverse agent exploration.
Fluoride and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) are established agents.
Emerging biomimetic agents represent a significant new direction in enamel remineralization research.