Bibliometric Analysis on Enamel Remineralization Agents

Dental caries remains a major global oral health concern, affecting almost 2.5 billion people. While restorative treatments remain widely used, modern dentistry increasingly focuses on preventive and minimally invasive approaches that strengthen the natural process of enamel remineralization. A comprehensive literature search was conducted in PubMed for enamel remineralization agents from 2015 to 2025. Clinical trials, randomized controlled trials, systematic reviews, and meta-analyses published in English were included. After screening, 153 publications were retained. RStudio (Biblioshiny package for the Bibliometrix tool, Posit Software, Boston, MA) was used to evaluate publication trends, citation impact, keyword structure, and collaboration networks. A total of 153 publications from 68 sources were identified, contributed by 700 authors, with an average annual growth rate of 10.65% and a mean document age of 4.58 years. Two waves of research activity were observed, with fluoride and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) dominating earlier years and biomimetic agents emerging more recently. This bibliometric mapping reveals enamel remineralization research as a field characterized by steady growth, global collaboration, and diversification of agent types. Fluoride and CPP-ACP continue to anchor the evidence base, while nanohydroxyapatite, bioactive glass, peptides, and natural products are emerging as promising contenders, driving the second wave of publications.