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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Acral Melanoma Following Trauma: A Systematic Review and Meta-Analysis.

Gabrielle J Williams1,2, John F Thompson1,2,3,4

  • 1Melanoma Institute Australia, The University of Sydney, NSW, Australia.

Journal of Cutaneous Medicine and Surgery
|April 17, 2026
PubMed
Summary
This summary is machine-generated.

Trauma history is more frequent in patients with acral melanoma. Early biopsy of concerning acral lesions after trauma is recommended for prompt diagnosis and treatment of acral melanoma.

Keywords:
acral site melanomainjurymeta-analysissystematic reviewtrauma

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Area of Science:

  • Dermatology
  • Oncology
  • Epidemiology

Background:

  • Anecdotal evidence suggests a link between trauma and acral melanoma.
  • High-quality supporting data for this association has been limited.

Purpose of the Study:

  • To systematically review and analyze the frequency of trauma in acral melanoma cases.
  • To compare tumor features, disease progression, and mortality in acral melanomas with and without a trauma history.

Main Methods:

  • Systematic review of Medline, Embase, and Cochrane CENTRAL databases up to May 15, 2025.
  • Inclusion of studies reporting acral melanoma cases with or without preceding trauma history.
  • Data pooling using a random-effects model for analysis.

Main Results:

  • Analysis of 97 studies confirmed a higher frequency of trauma history in acral melanoma patients (ORs 5.2 and 8.1).
  • Tumor features and mortality data were collated from case reports and multicase studies.
  • The evidence strongly supports the development of acral melanomas following trauma.

Conclusions:

  • Acral melanomas may develop subsequent to trauma.
  • Early biopsy of persistent or new acral lesions post-trauma is clinically significant.
  • Prompt diagnosis facilitates expeditious treatment of acral melanoma.