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Updated: Apr 19, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
ortho-Selective C-H Alkenylation of Pyridines Enabled by a Heterometallic Mg-Ni-Mg Complex
Haoyu Wen1, Yanping Cai1, Xin Xu1
1State Key Laboratory of Bioinspired Interfacial Materials Science & Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China.
Abstract:
This work reports the ortho-selective C-H alkenylation of diverse pyridines with alkynes catalyzed by the heterometallic Mg-Ni-Mg complex [(LMg)2Ni(C2H4)2] {L = [(DippNCMe)2CH]- and Dipp = 2,6-iPr2C6H3}. This protocol delivers a wide range of C2-alkenylpyridines with high regio- and stereoselectivities (>19:1 rr and >19:1 E/Z). The stoichiometric reaction of [(LMg)2Ni(C2H4)2] with 4-methylpyridine led to the isolation and structural characterization of a key C-H metalation intermediate, which provides direct evidence for a Mg-Ni cooperative ortho C-H activation process.
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