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Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

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Design and Analysis for Fall Detection System Simplification
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Trip Detection Algorithms for Healthy and Amputee Individuals.

Eugenio Anselmino, Tommaso Ciapetti, Michele Piazzini

    IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society
    |April 17, 2026
    PubMed
    Summary
    This summary is machine-generated.

    Researchers developed three algorithms for detecting trips in amputees using prosthetic legs. These methods show high accuracy and fast detection, improving safety and reducing fall risks for amputees.

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    Area of Science:

    • Biomechanics
    • Prosthetics
    • Robotics

    Background:

    • Amputation significantly impairs gait biomechanics, increasing fall risk due to reduced strength, balance, and toe clearance.
    • Falls in amputees lead to physical injuries and psychological distress.
    • Powered and microprocessor prosthetic legs require advanced algorithms for detecting external perturbations to enhance safety.

    Purpose of the Study:

    • To develop and validate novel algorithms for real-time trip detection in individuals with lower-limb amputations.
    • To assess the performance and generalization capabilities of different detection approaches (thresholds, machine learning, anomaly detection).
    • To achieve rapid and reliable perturbation detection for integration into prosthetic leg control systems.

    Main Methods:

    • Developed three distinct trip detection algorithms: threshold-based, machine learning-based, and anomaly detection-based.
    • Validated algorithms using data from 17 healthy subjects and 8 amputees (7 transtibial, 1 transfemoral) on a specialized tripping platform.
    • Acquired data capturing gait responses to unanticipated tripping perturbations.

    Main Results:

    • All developed algorithms demonstrated high performance, with median sensitivities exceeding 80% and specificities above 90%.
    • Algorithms trained on healthy subject data maintained high accuracy on amputee datasets, indicating strong generalization.
    • Detection times were consistently below 150 ms, with the threshold algorithm achieving the fastest average detection at approximately 40 ms.

    Conclusions:

    • The developed trip detection algorithms are viable solutions for real-time perturbation detection in prosthetic legs.
    • These algorithms offer fast detection times and high specificity, crucial for preventing falls in amputees.
    • The study highlights the potential for robust and generalizable trip detection across different user populations.