Related Experiment Video
Updated: Apr 19, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
Membrane lipids regulate the STING pathway and type I interferon responses
Yasmine Messaoud-Nacer1, Soumyabrata Guha1, Nadine Laguette1
1Institute of Molecular Genetics of Montpellier (IGMM), University of Montpellier, CNRS UMR5535, Montpellier, France.
Abstract:
The membrane lipid environment orchestrates stimulator of interferon genes (STING) signalosome assembly and downstream inflammatory responses. In two articles recently published in Nature, Li et al.1 and Tan et al.2 show that phosphoinositides and cholesterol cooperate to support canonical and non-canonical STING functions by potentiating agonist-dependent activation through oligomerization and trafficking. This level of regulation of STING activation highlights the crucial role of lipids in innate immune signaling.
Related Concept Videos
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Inhibitors of Viral Protein Synthesis
Antimicrobial Proteins
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Signal Transduction: Overview
Typically, signal transduction involves three...
IP3/DAG Signaling Pathway
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

