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Hallmarks of cancer research: Enabling transformative discovery through global team science
Rebecca L Eccles1, Gabriela Carreno1, Lorenzo de la Rica1
1Cancer Grand Challenges, Cancer Research UK, London, UK.
Cell
|April 17, 2026
Summary
Global team science advances cancer research beyond complex experiments. The Cancer Grand Challenges initiative supports collaborative efforts for transformative cancer discovery.
Area of Science:
- Oncology
- Cancer Research
- Translational Science
Background:
- The original Hallmarks of Cancer framework has been surpassed by a more complex understanding of cancer biology.
- Cancer research now requires navigating an evolving and intricate scientific ecosystem.
Purpose of the Study:
- To discuss strategies for supporting global team science in cancer research.
- To outline approaches for catalyzing transformative discoveries through collaboration.
Main Methods:
- Drawing on practical experience from the Cancer Grand Challenges initiative.
- Analyzing the operational and strategic aspects of large-scale collaborative research projects.
Main Results:
- Identifying key elements for successful global team science in oncology.
- Demonstrating the potential of structured collaboration to accelerate breakthroughs.
Conclusions:
- Effective support for global team science is crucial for advancing cancer research.
- The Cancer Grand Challenges model offers valuable insights into fostering transformative discoveries.
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