Instrumental conditioning of large-magnitude, daily, 12-hour blood pressure elevations in the baboon

Blood pressure and heart rate were monitored continuously in four baboons during extended exposure to a daily 12-hour conditioning procedure providing food and shock-avoidance as contingent consequences of prespecified increases in diastolic blood pressure. Sustained and significant increases (30 to 40 mm-Hg) in both systolic and diastolic blood pressure were maintained throughout the daily 12-hour conditioning sessions, accompanied by elevated heart rates.