Related Experiment Video
Updated: Apr 19, 2026
05:58
Site-Specific Lysine Lactylation via Genetic Code Expansion in E. coli and Mammalian Cells
Published on: February 24, 2026
450
Lactylation: Unlocking the regulatory code of exercise-mediated anti-aging
Xin Li1, Kang-Cheng Fan1, Gui-Yan Sun1
1College of Exercise and Health, Shenyang Sport University, Shenyang 110102, China.
Ageing Research Reviews
|April 17, 2026
Summary
Exercise promotes healthy aging by enhancing the "Exercise-Lactate-Lysine lactylation" axis. This process involves lactate signaling, which improves cellular functions and delays aging across multiple organ systems.
Area of Science:
- Aging and Metabolism
- Epigenetics and Exercise Science
Background:
- Aging involves metabolic dysfunction and epigenetic changes.
- Exercise is a key intervention, but its molecular mechanisms are unclear.
- Lactate, produced during exercise, is a crucial signaling molecule.
Purpose of the Study:
- To review the
- Exercise-Lactate-Lysine lactylation
- axis and its role in aging.
Main Methods:
- Systematic review of existing research.
- Analysis of molecular mechanisms linking exercise, lactate, and epigenetics.
- Evidence grading to assess research strength.
Main Results:
- Exercise-induced lysine lactylation (Kla) retards aging.
- Kla orchestrates mitochondrial health, immune balance, and stem cell regeneration.
- The axis shows cross-organ anti-aging effects in neurological, cardiovascular, musculoskeletal, and metabolic systems.
Conclusions:
- The
- Exercise-Lactate-Kla
- axis provides a framework for metabolism-epigenetics coupling in aging.
- This research supports precise exercise prescriptions and targeted anti-aging strategies.
More Related Videos
Related Concept Videos
01:46Epigenetic Regulation
34.6K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.6K
01:37Epigenetic Regulation
4.3K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
4.3K
01:46Epigenetic Regulation
26.7K
26.7K
02:15Replicative Cell Senescence
4.7K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.7K
02:15Replicative Cell Senescence
3.5K
3.5K
01:19The Effect of Aging on Tissues
4.2K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.2K