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Synthetic microbial co-cultures for modular bioelectronic sensing in diverse environments.

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We developed a modular bioelectronic sensor system (e-COSENS) for environmental and health monitoring. This plug-and-play system uses bacteria to detect various analytes, enabling portable signal readout.

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Area of Science:

  • Bioelectronic sensors
  • Microbial engineering
  • Environmental monitoring

Background:

  • Whole-cell bioelectronic sensors offer advantages for field monitoring but lack modularity and require specialized equipment.
  • Current designs are limited in microbial chassis and detection capabilities.

Purpose of the Study:

  • To develop a modular, plug-and-play system for whole-cell bioelectronic sensor development.
  • To enable versatile analyte detection in diverse environments using a simplified design.

Main Methods:

  • Introduced the electroactive co-culture sensing system (e-COSENS).
  • Utilized a 'sender' bacterium to produce mediators and a 'receiver' bacterium for signal generation via extracellular electron transfer.
  • Employed modular swapping of sender bacteria and genetic elements for sensing.

Main Results:

  • Demonstrated modular bioelectronic sensing of metals, small molecules, and peptides.
  • Successfully applied the system in various environments including urban waterways, milk, and saliva.
  • Developed a portable device for signal readout using a digital multimeter.

Conclusions:

  • The e-COSENS system simplifies whole-cell bioelectronic sensor design.
  • Expanded the application potential of bioelectronic sensors for diverse monitoring tasks.