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Published on: September 17, 2020
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Organellar insights in ageing and longevity
Philip Mannino1, Mooncheol Park1, Meng Carla Wang2
1HHMI Janelia Research Campus, Ashburn, VA, USA.
Nature Cell Biology
|April 17, 2026
Summary
Cellular organelles are key regulators of aging and longevity, influencing metabolic processes and signaling. Understanding organelle crosstalk and age-related changes offers new insights into promoting healthspan and lifespan.
Area of Science:
- Cellular Biology
- Aging Research
- Metabolism
Background:
- Metabolic processes are fundamental to aging and longevity.
- Organelles act as metabolic hubs and signaling centers, crucial for cellular homeostasis and organismal fitness.
- Organelle coordination and crosstalk are vital for maintaining cellular health.
Purpose of the Study:
- To summarize age-related changes in cellular organelles.
- To highlight the role of organelle-mediated signaling in lifespan and healthspan.
- To discuss the influence of organelles on microbiome-host interactions and transgenerational longevity inheritance.
Main Methods:
- Review of emerging evidence on organelle function in aging.
- Analysis of organelle crosstalk mechanisms (membrane contact sites, metabolite exchange, signaling).
- Exploration of organelle roles in microbiome-host interactions and inheritance.
Main Results:
- Organelles are increasingly recognized as critical regulators of aging and longevity.
- Organelle dynamics and communication are central to lifespan and healthspan.
- Interventions promoting longevity impact organelle function.
Conclusions:
- Organelle coordination is essential for cellular homeostasis and organismal fitness.
- Understanding organelle roles in aging can lead to novel longevity interventions.
- Future technological advancements will accelerate research in organelle-mediated longevity.
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