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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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Age-Related Adaptations in Renal Tubular Function in Female Rats.

Aurélie Edwards1, Timothy M Reilly2, Donna L Ralph2

  • 1Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA.

Acta Physiologica (Oxford, England)
|April 18, 2026
PubMed
Summary
This summary is machine-generated.

Aging female rats show altered kidney function, with higher filtration but reduced sodium transporter abundance. This suggests an increased risk of sodium retention, impacting studies on hypertension and kidney disease.

Keywords:
age differencesmathematical modelnephronrenal transportersrenal tubule

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Area of Science:

  • Nephrology and aging research
  • Renal physiology and chronic disease mechanisms

Background:

  • Mature animal models are crucial for studying adult chronic diseases.
  • Age and parity significantly influence physiological processes, including renal function.

Purpose of the Study:

  • To investigate the impact of aging and prior pregnancy on renal function in Sprague Dawley female rats.
  • To compare glomerular filtration, tubular transport, and transporter abundance between young and aged, nulliparous and multiparous rats.

Main Methods:

  • Comparison of glomerular filtration rate (GFR), urinary excretion, and diuretic/electrolyte challenge responses.
  • Quantification of renal tubule transporter abundance and sodium pump activity.
  • Physiological modeling to assess age-related changes in tubular transport and energetics.

Main Results:

  • Aged (12-month) rats exhibited ~25% higher GFR than young (4.5-month) rats, with lower key sodium (Na+) transporter abundance but higher aquaporin-2 (AQP2).
  • Older rats showed slower saline excretion but greater Na+ excretion after furosemide and hydrochlorothiazide challenges.
  • Kidney adaptation involves increased proximal nephron reabsorption capacity and decreased Na+ transporter abundance to balance higher filtration rates.

Conclusions:

  • Aging female rats demonstrate physiological adaptations in the kidney, potentially leading to increased sodium retention.
  • These age-related changes in renal function are important considerations for research into hypertension and kidney disease.