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Diabetic Neuropathy

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...

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Inspiratory Muscle Training as an Adjunct to the Treatment of Weaning Failure in Critically Ill Patients: A Practical Guide

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Multifactorial Inspiratory Muscle Training in Patients With Diabetic Polyneuropathy: A Qualitative Study.

Suman Sheraz¹, Arshad Nawaz Malik¹, Francesco Vincenzo Ferraro²

¹Faculty of Rehabilitation and Allied Health Sciences, Riphah International University, Islamabad, Pakistan, riphah.edu.pk.

Journal of Diabetes Research

|April 18, 2026

Summary

Patients with diabetic polyneuropathy found multifactorial home-based inspiratory muscle training (IMT) improved quality of life and physical health. Key barriers included usage difficulty and home environment distractions, highlighting the need for tailored interventions.

Keywords:

Type II diabetes mellitus diabetic polyneuropathy health-related quality of life (HrQoL)patient′s perceptions

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Published on: July 5, 2017

Area of Science:

Rehabilitation Medicine
Neurology
Diabetology

Background:

Diabetic polyneuropathy significantly impacts patients' quality of life.
Home-based multifactorial interventions are crucial for managing chronic conditions like diabetic polyneuropathy.

Purpose of the Study:

To explore patient perspectives on home-based multifactorial inspiratory muscle training (IMT) combined with the Otago Exercise Program (OEP).
To identify facilitators and barriers influencing intervention adherence and outcomes in diabetic polyneuropathy patients.

Main Methods:

Descriptive qualitative study employing individual semistructured interviews with 12 patients.
Thematic analysis of transcribed and translated interview data (Urdu to English).

Main Results:

Patients reported improved quality of life, physical and mental health, and functional independence.
Key barriers included initial usage difficulty, discomfort, and home environment distractions.
Perceived benefits encompassed improvements in shortness of breath and walking capacity.

Conclusions:

Multifactorial IMT interventions demonstrate positive effects on the physical, mental, and emotional health of diabetes patients.
Tailoring interventions to address identified barriers and facilitators is essential for successful outcomes in diabetic polyneuropathy management.