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Postbiotic_Loaded Hyalurosome: Investigating Their Potential as Antimicrobial and Antioxidant Agents
Seyede Fateme Morakabi1, Mahvash Khodabandeh Shahraky1, Gholamreza Ahmadian1
1National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
Journal of Cosmetic Dermatology
|April 18, 2026
Summary
Lactic acid bacteria postbiotics encapsulated in hyalurosomes show potent antibacterial and antioxidant effects for skincare. This dual-action delivery system enhances safety and efficacy against skin dysbiosis and oxidative stress.
Area of Science:
- Dermatology
- Microbiology
- Nanotechnology
- Biochemistry
Background:
- The skin microbiota is crucial for skin health, but imbalances can cause disorders.
- Postbiotics, derived from probiotic fermentation, offer natural antimicrobial and antioxidant benefits for skincare.
Purpose of the Study:
- To evaluate antibacterial and antioxidant properties of postbiotics from four lactic acid bacteria (LAB).
- To encapsulate potent LAB postbiotics into hyaluronic acid-based nanoparticles (hyalurosomes) for improved topical delivery.
Main Methods:
- Antibacterial and antioxidant assays (DPPH assay, MIC, MBC).
- Nanoparticle synthesis, characterization, and cytotoxicity testing.
- Growth curve analysis and supernatant preparation.
Main Results:
- Lacticaseibacillus rhamnosus (LGG) showed broad-spectrum antibacterial activity against Micrococcus luteus.
- Weizmannia coagulans (WCO) exhibited superior antioxidant capacity, outperforming ascorbic acid.
- Hyalurosomes enhanced postbiotic bioactivity and significantly reduced cytotoxicity to human dermal fibroblasts.
Conclusions:
- LAB-derived postbiotics encapsulated in hyalurosomes present a safe and effective dual-strategy for skincare.
- This approach targets both microbial dysbiosis and oxidative stress in advanced skincare formulations.
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