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Dynamically Crosslinked Carbon Dot/Alginate Hydrogels for On-Demand Osteomyelitis Therapy.

Yang Wang1, Siyuan Ma1, Yan Zhao2

  • 1Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Advanced Materials (Deerfield Beach, Fla.)
|April 18, 2026
PubMed
Summary

This study developed a novel hydrogel using carbon dots (CDs) to combat osteomyelitis. The innovative material effectively fights infection, reduces inflammation, and promotes bone healing for improved orthopedic treatment.

Keywords:
anti‐inflammatory and antibacterial activitycarbon dotshydrogelson‐demand therapyosteogenic activityosteomyelitis therapy

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Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Nanotechnology

Background:

  • Osteomyelitis is a challenging orthopedic condition requiring advanced therapeutic strategies.
  • Current treatments often struggle with multifactorial aspects like infection, inflammation, and bone regeneration.
  • There is a critical need for responsive materials that can address these challenges simultaneously.

Purpose of the Study:

  • To design and fabricate a novel, multifunctional hydrogel platform for on-demand osteomyelitis therapy.
  • To engineer carbon dots (CDs) with specific functionalities for antibacterial, anti-inflammatory, and osteogenic activities.
  • To create dynamic-crosslinked hydrogels capable of bacteria-specific and controlled release of therapeutic agents.

Main Methods:

  • Modification of carbon dots (CDs) with catechol and doping with Se─Se bonds.
  • Construction of dynamically crosslinked composite hydrogels using catechol-functionalized Se-doped CDs.
  • Utilizing dissociable borate ester bonds for hydrogel network formation.
  • In vivo evaluation of the hydrogel's efficacy in a MRSA-induced osteomyelitis model.

Main Results:

  • The developed CD-based hydrogels exhibited significant antibacterial, anti-inflammatory, and osteogenic properties.
  • The hydrogels demonstrated bacteria-specific and controllable release of CDs.
  • Near-complete healing of bone defects was achieved in the osteomyelitis model.
  • The dynamic crosslinking enabled responsive material behavior.

Conclusions:

  • This work presents a paradigm for creating dynamic-crosslinked hydrogels from multifunctional carbon dots.
  • The developed hydrogel platform offers a promising strategy for simultaneous regulation of infection, inflammation, and bone repair in osteomyelitis.
  • This approach facilitates on-demand osteomyelitis therapy with enhanced therapeutic outcomes.