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Inverse relationship between Epstein-Barr virus serostatus and anti-glutamic acid decarboxylase autoantibody levels

Cyril Debuysschere1, Mahdi Ouafi1, Magloire Pandoua Nekoua1

  • 1Laboratoire de virologie ULR3610, Univ Lille et CHU Lille, Lille, France.

Immunologic Research
|April 18, 2026
PubMed
Abstract

No abstract available in PubMed .

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Enzyme-Linked Immunosorbent Assay01:33

Enzyme-Linked Immunosorbent Assay

In 1971, Peter Perlman and Eva Engvall developed an Enzyme-linked immunosorbent assay (ELISA or EIA). ELISA differs from western blot in that the assays are conducted in microtiter plates or in vivo rather than on an absorbent membrane.
There are many different types of ELISAs, but they all involve an antibody molecule whose constant region binds an enzyme, leaving the variable region free to bind its specific antigen.  Enzyme-substrate reaction allows the antigen to be visualized or quantified.
Keywords:
AutoantibodiesAutoimmunityEBVEpstein Barr virusGAD antibodiesGlutamic acid decarboxylasePancreatic islet autoimmunity