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Bioactive polycyclic polyprenylated acylphloroglucinols from Hypericum maclarenii
Wen-Lan Meng1, Yu Zhou1, Fei-Fei Xiong1
1State Key Laboratory of Phytochemistry and Natural Medicines, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
None:
The first phytochemical investigation on the aerial parts of Hypericum maclarenii resulting in the characterization of seven new polycyclic polyprenylated acylphloroglucinols (PPAP), hypermacones A - G (1-7), together with nine known analogues. Their structures and absolute configurations were determined by using comprehensive spectroscopic techniques and electronic circular dichroism (ECD) calculations. The cytotoxic activities of compounds 1-16 were evaluated against five human cancer cell lines, compounds 2 and 7 exhibited moderate inhibitory activities.
