Nuclear segmentation in goitre aspirates

Nuglear segmentation was studied in fine needle aspirate smears from toxic and atoxic goitres. The smear technique implies a flattening of the nuclei on a slide, which facilitates detection of nuclear segmentation. Such segmentation was found in 2.2% of the nuclei in toxic goitres and in 0.9% in atoxic goitres. The difference was highly significant p less than 0.001. The segmented cells were usually of uniform appearance with one large and one small segment. Only very rarely were more than two segments seen.