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Medicinal chemistry strategies to breach the blood-brain barrier: structural design principles for brain-targeted

Harikesh Kumar Gupta1, Jatin Jangra1, Vishwakarma Krishna Ramesh1

  • 1Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, Uttar Pradesh 221005, India.

Drug Discovery Today
|April 18, 2026
PubMed

Keywords:
CNS drug designPAMPA-BBB assaybrain-to-plasma ratiomedicinal chemistry strategiesphysicochemical parametersstructural modifications

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