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Updated: Apr 20, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

Targeting S1P signaling for drug development.

Yaru Liu¹, Yali Song¹, Youzhi Wang²

¹College of Pharmaceutical Sciences, Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Education Ministry of China, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China.

Drug Discovery Today

|April 18, 2026

Summary

This summary is machine-generated.

Sphingosine-1-phosphate (S1P) regulates cell functions and immune cell movement, impacting various diseases. This review covers S1P modulators, their generation, transport, degradation, and structure-activity relationships.

Keywords:

drug development modulators signal transduction sphingosine-1-phosphate

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Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors

Published on: July 17, 2020

Area of Science:

Biochemistry
Cell Biology
Pharmacology

Background:

Sphingosine-1-phosphate (S1P) is a key sphingolipid metabolite with diverse biological roles.
S1P influences cell proliferation, migration, and immune cell trafficking, implicating it in various diseases.
Current therapeutics include S1P receptor agonists for multiple sclerosis and S1P production inhibitors in cancer trials.

Purpose of the Study:

To review modulators of Sphingosine-1-phosphate (S1P).
To discuss the generation, transportation, and degradation of S1P.
To explore preliminary structure-activity relationships of S1P modulators.

Main Methods:

Literature review of S1P modulators.
Analysis of S1P generation, transport, and degradation pathways.
Examination of structure-activity relationships for S1P modulators.

Main Results:

Identification of various modulators targeting S1P pathways.
Understanding of S1P's complex roles in biological processes.
Preliminary insights into structure-activity relationships guiding drug development.

Conclusions:

S1P modulators represent a significant therapeutic avenue for multiple sclerosis and cancer.
Further research into S1P modulators and their structure-activity relationships is warranted.
Targeting S1P pathways offers potential for treating a wide spectrum of diseases.