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Microenvironment engineering with injectable hydrogel-based biofunctional scaffolds for augmenting bone defect

Yilong Dong1, Yang Fei2, Yan Hu3

  • 1Ruian People's Hospital, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325200, China.

Journal of Nanobiotechnology
|April 18, 2026
PubMed
Summary
This summary is machine-generated.

Injectable hydrogels offer a promising solution for bone defect repair, overcoming limitations of traditional bone grafts. These advanced biomaterials enhance bone regeneration through tailored microenvironments and targeted therapeutic delivery for minimally invasive treatments.

Keywords:
Bone defect healingBone microenvironment remodelingInjectable hydrogel scaffoldsLocalized drug delivery

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Surgery

Background:

  • Bone defects are prevalent clinical issues requiring bone grafts for regeneration.
  • Current bone grafts face challenges including invasive surgery, limited efficacy, and availability.
  • Injectable hydrogels present a biocompatible, adaptable alternative for bone repair.

Purpose of the Study:

  • To review the development of injectable hydrogel-based biomaterials for bone defect repair.
  • To explore strategies for enhancing osteoinductivity in hydrogel scaffolds.
  • To discuss future directions for injectable hydrogels in bone regeneration.

Main Methods:

  • Review of literature on injectable hydrogels for bone defect treatment.
  • Analysis of gelling mechanisms and osteoinductive properties of hydrogels.
  • Discussion of therapeutic delivery systems and material-biointeractions.

Main Results:

  • Injectable hydrogels show potential for bone regeneration due to biocompatibility and malleability.
  • Osteoinductive microenvironments and localized drug delivery enhance osteogenesis.
  • Hydrogels can be functionalized to support and guide bone healing.

Conclusions:

  • Injectable hydrogels are a promising platform for minimally invasive bone defect treatment.
  • Further research on therapeutic persistence, degradability, and cost-effectiveness is needed.
  • Optimizing dynamic material-biointeractions will advance clinical applications.