Clinical assessment and early intervention for deviations in children's growth and development

Area of Science:

• Pediatric Endocrinology
• Child Growth and Development
• Clinical Interventions

Background:

• Chinese children's height has increased, yet parental awareness of growth factors remains low.
• Growth disorders in children require timely clinical and pharmacological interventions.
• Early detection of deviations is crucial for effective management.

Purpose of the Study:

• To analyze clinical and early pharmacological interventions for growth deviations in children.
• To evaluate treatments for preventing and treating growth disorders.
• To promote normal growth in children with height deviations.

Main Methods:

• A retrospective study of 120 children with growth deviations (SS, LSS, ED, CPP groups).
• Interventions included oral medications (lysine, inositol, vitamin B12, GABA, Zhi Bai Di Huang Wan) and health guidance.
• Collected and compared height growth, growth factors, and pre-treatment factors.

Main Results:

• All children showed height increases after 3-6 months, with the fastest growth in the less short stature (LSS) group.
• Logistic regression identified sex and pre-treatment age as key height predictors.
• Receiver operating characteristic (ROC) curves indicated predictive value for sex, age, and a combined model.

Conclusions:

• Early clinical analysis and intervention for growth deviations can normalize growth.
• Interventions can slow bone age advancement and improve final height outcomes.
• Effective prevention and treatment of pediatric growth disorders are achievable.