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Updated: Apr 21, 2026
Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma
Published on: July 25, 2011
Identification of high-risk patients and metastatic progression in primary c/pN0 oral squamous cell carcinoma
R Eloranta1, R Nikkilä, S Vilén
1Riikka Eloranta Department of Oral and Maxillofacial Diseases Helsinki University Hospital, Helsinki, FI-00029 HUS, Finland riikka.eloranta@gmail.com.
Background:
Metastasis significantly decreases survival in oral cavity squamous cell carcinoma (OSCC). Even patients initially staged as cN0 may develop cervical or distant metastases during follow-up. Risk factors contributing to metastasis in this group are not fully understood.
Materials And Methods:
A retrospective cohort study was conducted on patients with primary cN0 OSCC treated between 2016 and 2020.
Results:
Of the 195 N0 OSCC patients included, 19 (9.7%) developed metastasis. Heavy alcohol use (HR 4.05, 95% CI:1.38-11.92, p=0.011) and depth of invasion (DOI) (HR 1.10, 95% CI:1.01-1.20, p=0.021) were significantly associated with the development of metastasis. Age, gender, site, neck procedure, radiotherapy, and T-class were not statistically significant predictors in this analysis.
Conclusions:
Metastases occurred in nearly 10% of c/pN0 patients. Alcohol use and DOI were independent predictors, highlighting the need for individualized follow-up strategies and further research into alcohol-related OSCC.
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