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Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks
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Metal organic frameworks for biosensing applications: A bibliometric analysis (2015-2025).

Narendra Kumar1, Mangey Ram Nagar2, Niraj Agrawal3

  • 1Department of Biotechnology, Noida Institute of Engineering and Technology, India.

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|April 19, 2026
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Summary

Metal-organic frameworks (MOFs) are versatile platforms for biosensing, with research rapidly expanding since 2019. China leads global publications, focusing on electrochemical and nanozyme-based sensing for diagnostics and environmental monitoring.

Keywords:
Bibliometric analysisBiosensingMetal organic frameworks, FluorescenceResearch trend

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Area of Science:

  • Materials Science, Analytical Chemistry, Nanotechnology

Background:

  • Metal-organic frameworks (MOFs) offer tunable porosity, surface area, and functional versatility, making them ideal for biosensing.
  • Recent advancements in MOF synthesis, nanozyme conjugation, and electrochemical sensors have accelerated their application in diagnostics and safety testing.

Purpose of the Study:

  • To systematically review global research trends in MOF-based biosensing from 2015 to 2025.
  • To analyze publication growth, key research areas, and international collaboration patterns.

Main Methods:

  • Bibliometric analysis of 2664 articles from the Scopus database (2015-2025).
  • Utilized VOSviewer for network analysis of publications, authorship, keywords, and co-citations.
  • Identified key thematic domains and collaboration patterns.

Main Results:

  • A significant annual increase in publications, particularly post-2019, indicates heightened research activity.
  • China dominates publications, largely supported by national funding.
  • Five major research themes emerged: electrochemical biosensing, nanozyme catalysis, luminescence detection, biomarker diagnostics, and material synthesis.

Conclusions:

  • MOF-based biosensing is a rapidly growing field with increasing global research output.
  • Key research areas include electrochemical and nanozyme-based approaches for diverse applications.
  • Future efforts should focus on interdisciplinary collaboration for translational advancements in biosensing technologies.