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Metal organic frameworks for biosensing applications: A bibliometric analysis (2015-2025)
Narendra Kumar1, Mangey Ram Nagar2, Niraj Agrawal3
1Department of Biotechnology, Noida Institute of Engineering and Technology, India.
Talanta
|April 19, 2026
Summary
Metal-organic frameworks (MOFs) are versatile platforms for biosensing, with research rapidly expanding since 2019. China leads global publications, focusing on electrochemical and nanozyme-based sensing for diagnostics and environmental monitoring.
Area of Science:
- Materials Science, Analytical Chemistry, Nanotechnology
Background:
- Metal-organic frameworks (MOFs) offer tunable porosity, surface area, and functional versatility, making them ideal for biosensing.
- Recent advancements in MOF synthesis, nanozyme conjugation, and electrochemical sensors have accelerated their application in diagnostics and safety testing.
Purpose of the Study:
- To systematically review global research trends in MOF-based biosensing from 2015 to 2025.
- To analyze publication growth, key research areas, and international collaboration patterns.
Main Methods:
- Bibliometric analysis of 2664 articles from the Scopus database (2015-2025).
- Utilized VOSviewer for network analysis of publications, authorship, keywords, and co-citations.
- Identified key thematic domains and collaboration patterns.
Main Results:
- A significant annual increase in publications, particularly post-2019, indicates heightened research activity.
- China dominates publications, largely supported by national funding.
- Five major research themes emerged: electrochemical biosensing, nanozyme catalysis, luminescence detection, biomarker diagnostics, and material synthesis.
Conclusions:
- MOF-based biosensing is a rapidly growing field with increasing global research output.
- Key research areas include electrochemical and nanozyme-based approaches for diverse applications.
- Future efforts should focus on interdisciplinary collaboration for translational advancements in biosensing technologies.

