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Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
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Heterogeneous nuclear ribonucleoprotein C deficiency compromises extracellular matrix-receptor interaction and

Gangfeng Ding1, Jiayao He1, Yichao Chen1

  • 1The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, China.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|April 19, 2026
PubMed

Insights

Heterogeneous nuclear ribonucleoprotein C (HNRNPC) is upregulated in esophageal cancer (EC), driving tumor growth by inhibiting apoptosis. Suppressing HNRNPC shows promise for treating this aggressive cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Esophageal cancer (EC) is aggressive with poor survival rates.
  • N6-methyladenosine (m6A) modification regulates gene expression and disease.
  • HNRNPC, an m6A reader, is implicated in various cancers but its role in EC is unknown.

Purpose of the Study:

  • To investigate the function and mechanism of HNRNPC in esophageal cancer.
  • To determine the correlation between HNRNPC expression and EC prognosis.

Main Methods:

  • Analysis of public databases and a clinical cohort.
  • In vivo studies using a xenograft mouse model.
  • Molecular analyses of gene expression and cellular processes.

Main Results:

  • HNRNPC was upregulated in EC and associated with poor prognosis.
  • HNRNPC knockdown suppressed tumor growth in vivo by promoting apoptosis.
  • HNRNPC deficiency affected complex transcripts and disrupted extracellular matrix-receptor interactions.

Conclusions:

  • HNRNPC promotes esophageal cancer progression.
  • Targeting HNRNPC may be a potential therapeutic strategy for EC.
  • HNRNPC influences EC tumorigenesis through modulation of specific gene networks.
Keywords:
Complex transcriptsECM-receptor interactionEsophageal squamous cell carcinomaHeterogeneous nuclear ribonucleoprotein C (HNRNPC)RNA methylation

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