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Cardiovascular Magnetic Resonance in Cardiac Amyloidosis: Part I-Technical Foundations, Techniques, and Endpoints
Chi Yang Chen1, Jose Alvarez-Cardona1, Ana Barac2
1NYU Langone Cardiology Associates - 5th Floor, 530 1st Avenue, HCC 5th Floor, New York, NY 10016, USA.
None:
Amyloidosis is a systemic disease characterized by the extracellular deposition of the misfolded proteins resulting in organ dysfunction, frequently the heart. Cardiac amyloidosis is an underrecognized cause of heart failure which carries significant morbidity and mortality when its diagnosis is delayed. Cardiac magnetic resonance (CMR) imaging has emerged as critical technique in diagnosis of cardiac amyloidosis through its unique ability to non-invasively measure myocardial tissue characteristics and changes in extracellular volume. In turn, CMR allows differential diagnosis, early detection, and precise characterization of amyloid disease pathology. This review focuses on the technical foundations of CMR relevant to cardiac amyloidosis.
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Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...