Related Experiment Video
Updated: Apr 21, 2026
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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Pathophysiology of Odontogenic Maxillary Sinusitis Arising from Marginal Periodontitis with Ascending Pulpitis
Kiminori Sato1, Shun-Ichi Chitose1, Kiminobu Sato1
1Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine.
The Kurume Medical Journal
|April 20, 2026
Summary
Marginal periodontitis can cause ascending pulpitis and pulpal necrosis, leading to apical periodontitis and oral-maxillofacial space infection (OMS). This pathway is crucial for diagnosis, especially without coronal lesions.
Area of Science:
- Dentistry
- Oral Pathology
Background:
- Ascending pulpitis involves inflammation progressing from the tooth apex coronally.
- Oral-maxillofacial space infection (OMS) can arise from various sources, including dental infections.
Purpose of the Study:
- To investigate the pathophysiology of OMS originating from marginal periodontitis with ascending pulpitis.
- To identify the pathological sequence linking marginal periodontitis to OMS.
Main Methods:
- Histological analysis of teeth from five adult patients diagnosed with OMS due to marginal periodontitis.
- Examination of clinical presentation, focusing on the absence of coronal lesions.
Main Results:
- No coronal lesions were found in the affected teeth.
- Histology confirmed marginal periodontitis, ascending pulpitis, pulpal necrosis, and apical periodontitis.
- A pathological sequence was proposed: marginal periodontitis → ascending pulpitis/pulpal necrosis → apical periodontitis → OMS.
Conclusions:
- Diagnosing ascending pulpitis and pulpal necrosis is challenging without coronal lesions.
- Understanding the progression from marginal periodontitis to OMS is essential for clinicians.
- A high index of suspicion is necessary for timely diagnosis and management.
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