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The Function of PPARα in Cancer Drug Development: A Promising Target for Cancer Treatment

Rasiravathanahalli Kaveriyappan Govindarajan1,2, Ragothaman Prathiviraj3, Mohammed Qasim Waheeb4

  • 1Department of Biotechnology, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, 641021, India.

Current Cancer Drug Targets
|April 20, 2026
PubMed

Insights

Peroxisome proliferator-activated receptor alpha (PPARα) modulators show promise in cancer treatment. This review explores PPARα

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Cancer remains a leading global cause of mortality.
  • Peroxisome proliferator-activated receptors (PPARs) and their modulators are implicated in cancer progression.
  • PPARα, a nuclear hormone receptor, influences carcinogenesis through various pathological cancer behaviors.

Purpose of the Study:

  • To review the current understanding of PPARα's role in different facets of cancer development.
  • To summarize known modulators that regulate PPARα activity.
  • To discuss the potential for developing PPARα-targeting modulators for cancer therapy.

Main Methods:

  • Literature review of existing research on PPARα in cancer.
  • Analysis of studies detailing PPARα's mechanisms in carcinogenesis.
  • Synthesis of information on PPARα modulators and their therapeutic potential.

Main Results:

  • PPARα activation influences key cancer cell behaviors, including proliferation and inflammation.
  • Specific transcriptional pathways and immune responses are modulated by PPARα.
  • Evidence highlights PPARα's complex role in various cancer types.

Conclusions:

  • PPARα is a significant factor in cancer development and progression.
  • Targeting PPARα with specific modulators presents a potential therapeutic strategy for cancer.
  • Further research into PPARα modulators could lead to novel cancer treatments.
Keywords:
PPARPPARαagonistantagonistcancercancer treatmentmodulators

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