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Octreotide Counteracts IFN-γ-Induced Endothelial Inflammation.

Saikat Fakir1, Madan Sigdel1, Md Matiur Rahman Sarker1

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Journal of Biochemical and Molecular Toxicology
|April 20, 2026
PubMed
Summary
This summary is machine-generated.

Octreotide (OCT) protects endothelial cells from inflammatory damage caused by interferon-gamma (IFN-γ). This study shows OCT reduces hyperpermeability and oxidative stress, supporting its role in vascular health.

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Area of Science:

  • Vascular Biology
  • Immunology
  • Pharmacology

Background:

  • Endothelial cells are crucial for vascular homeostasis, regulating permeability and coagulation.
  • Interferon-gamma (IFN-γ) disrupts endothelial barrier function, contributing to inflammatory conditions.
  • Octreotide (OCT), a somatostatin analog, is known for its effects on hormone secretion and tumor growth.

Purpose of the Study:

  • To investigate the anti-inflammatory and cytoprotective effects of Octreotide (OCT) on interferon-gamma (IFN-γ)-induced endothelial injury.
  • To explore OCT's impact on key signaling pathways involved in endothelial dysfunction.

Main Methods:

  • Endothelial cells were subjected to IFN-γ stimulation to induce injury.
  • The effects of OCT treatment on cellular signaling pathways (cofilin, MLC2, JAK2, STAT1, STAT3, P38) were assessed.
  • Endothelial hyperpermeability and reactive oxygen species (ROS) generation were measured.

Main Results:

  • OCT significantly suppressed the activation of cofilin, MLC2, JAK2, STAT1, STAT3, and P38 induced by IFN-γ.
  • OCT treatment reduced IFN-γ-induced endothelial hyperpermeability.
  • OCT diminished reactive oxygen species (ROS) generation in response to IFN-γ.

Conclusions:

  • Octreotide exhibits anti-inflammatory and cytoprotective properties against IFN-γ-induced endothelial injury.
  • OCT mitigates endothelial barrier dysfunction by inhibiting key inflammatory signaling pathways and reducing oxidative stress.
  • These findings support the potential therapeutic role of somatostatin analogs in endothelium-dependent disorders like lung injury and sepsis.