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Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Blood Transfusion and Agglutination02:45

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
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The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
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Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
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Articles linked to this work by shared authors, journal, and citation graph.

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Early Haemoglobin response after single-unit red blood cell transfusion predicts repeat transfusion in hospitalised adults: A prospective cohort study and clinical prediction model.

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Related Experiment Video

Updated: Apr 21, 2026

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
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A Clinical Prediction Model for Inadequate Hemoglobin Response After Red Blood Cell Transfusion.

Rudraksh Kesharwani1, Ritika Agarkar2, Dhruvin Patel3

  • 1District Hospital, Bilaspur, Chhattisgarh, India.

European Journal of Haematology
|April 20, 2026
PubMed
Summary

Approximately 20% of patients show inadequate hemoglobin response after packed red blood cell transfusion. Higher baseline hemoglobin and splenomegaly are key predictors, informing clinical decisions and reducing unnecessary transfusions.

Keywords:
hemoglobin incrementpatient blood managementprediction modelred blood cell transfusiontransfusion response

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Area of Science:

  • Hematology
  • Transfusion Medicine
  • Clinical Research

Background:

  • Packed red blood cell transfusion aims to increase hemoglobin by ~1 g/dL.
  • Variability in hemoglobin response is common, raising concerns about bleeding or hemodilution.
  • Predictors of inadequate response can improve interpretation of post-transfusion values.

Purpose of the Study:

  • To identify predictors of inadequate hemoglobin response after single-unit red blood cell transfusion.
  • To develop a clinical prediction model for assessing transfusion response.
  • To aid clinicians in interpreting post-transfusion hemoglobin levels.

Main Methods:

  • Prospective observational cohort study of 518 adults receiving one unit of RBCs.
  • Hemoglobin measured at baseline and 12, 24, 48 hours post-transfusion.
  • Inadequate response defined as <1 g/dL hemoglobin increase at 24 hours (ΔHb24); multivariable logistic regression used.

Main Results:

  • Mean ΔHb24 was 1.41 g/dL; 20.5% of patients had inadequate response.
  • Higher baseline hemoglobin and splenomegaly were independent predictors of inadequate response.
  • A prediction model showed moderate discrimination (AUC 0.64) and acceptable calibration.

Conclusions:

  • Inadequate hemoglobin response occurs in ~20% of patients, influenced by recipient factors.
  • A simplified clinical prediction score can help stratify risk for inadequate response.
  • The model may assist in interpreting post-transfusion hemoglobin and reducing repeat transfusions.