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Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Related Experiment Video

Updated: Apr 21, 2026

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

Relationships between morphological score changes during embryonic development and pregnancy outcomes.

Qiuying Gan^1,2, Wenhong Ma², Lidan Liu¹

¹Reproductive Medicine Center, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Clinical and Experimental Reproductive Medicine

|April 20, 2026

Summary

Day 5 embryo morphology is key for predicting pregnancy success, with excellent Day 5 embryos showing the best outcomes. Day 3 scores offer additional insights for selecting top embryos, improving clinical pregnancy and live birth rates.

Keywords:

Cleavage embryos Clinical outcome In vitro fertilization and embryo transfer Morphological score Single blastocyst transfer

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Last Updated: Apr 21, 2026

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

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Published on: December 5, 2015

A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse

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Published on: October 24, 2017

High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo

High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo

Published on: November 8, 2018

Area of Science:

Reproductive Medicine
Embryology
In Vitro Fertilization

Background:

Optimal blastocyst selection is crucial for improving IVF success rates.
Embryonic morphological scoring is a common method for assessing embryo quality.
Predicting pregnancy outcomes requires understanding the significance of morphological changes during embryonic development.

Purpose of the Study:

To investigate the predictive value of embryonic morphological score changes for pregnancy outcomes.
To determine if day 3 and day 5 blastocyst morphology, along with developmental changes, impact clinical pregnancy rate (CPR) and live birth rate (LBR).
To support optimal blastocyst selection strategies in IVF.

Main Methods:

A retrospective analysis of 1,492 single blastocyst transfers across two centers.
Blastocysts were categorized by Day 3 and Day 5 scores (excellent, good, poor).
Embryonic morphological changes from Day 3 to Day 5 were classified as improvement, stability, or deterioration.

Main Results:

Excellent Day 5 morphology was significantly associated with higher CPR and LBR compared to poor Day 5 morphology.
No significant differences in CPR or LBR were found based on Day 3 scores alone or on the developmental changes (improvement, stability, deterioration) from Day 3 to Day 5.
Poor Day 3 embryos that developed into Excellent Day 5 embryos had a lower LBR than those that were Excellent Day 5 from the start.

Conclusions:

Day 5 blastocyst morphology is the primary predictor of clinical pregnancy and live birth rates.
While Day 3 to Day 5 morphological changes did not significantly alter outcomes, Day 3 scores provide supplementary information for selecting top-tier Day 5 embryos.
Integrating Day 3 and Day 5 morphological assessments can enhance embryo selection for improved IVF success.