Related Experiment Video
Updated: Jun 10, 2026

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
Published on: July 5, 2017
The Effect of Cranberry Consumption on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled
Leyli Zahra Bahreyni1, Mohammad Reza Amini2, Leila Sheikhi3
1Student Research Committee, Department of Clinical Nutrition & Dietetics, National Nutrition & Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Insights
Cranberry consumption did not significantly lower blood pressure in this meta-analysis. However, specific subgroups like females or those with normal BMI showed potential benefits for systolic and diastolic blood pressure.
Area of Science:
- Cardiovascular Health
- Nutritional Science
- Evidence-Based Medicine
Background:
- Elevated blood pressure is a major risk factor for cardiovascular disease.
- Cranberry consumption is explored for its potential health benefits, including blood pressure management.
- Randomized controlled trials (RCTs) provide evidence on cranberry's impact on blood pressure.
Conclusions:
- Cranberry consumption, as a whole, does not appear to be an effective strategy for managing SBP and DBP.
- Specific consumption patterns (e.g., juice form, duration) and participant characteristics (e.g., age, gender, BMI) may influence cranberry's effect on blood pressure.
- Further research is warranted to clarify the conditions under which cranberry may impact blood pressure.
Background:
The aim of this paper, which includes a meta-analysis, is to elucidate the effects of cranberry consumption on systolic and diastolic blood pressure based on all relevant randomized controlled trials (RCTs).
Materials And Methods:
A systematic literature search was performed across the ISI Web of Science, PubMed, Embase, the Cochrane Library, and Google Scholar databases, encompassing trials published until December 2024. Weighted mean differences (WMD) were calculated using random or fixed-effects models. Between-study heterogeneity was evaluated using Cochrane's test and the I² index. This study's registration number in PROSPERO is CRD420251028424.
Results:
A total of 1204 publications were reviewed, leading to the inclusion of 12 trials for qualitative synthesis and meta-analysis. The pooled effect size indicated statistically nonsignificant reductions of 1.31 mmHg for systolic blood pressure (SBP) (p = 0.19) and 1.31 mmHg for diastolic blood pressure (DBP) (p = 0.12). Stratified analysis showed that the reduction in SBP was statistically significant in studies where cranberry was provided in juice form, with a duration of 8 weeks or less, involving participants with a mean age of < 50 years, and predominantly in females. Furthermore, subgroup analysis indicated a significant reduction in DBP in studies that involved both genders, lasted more than 8 weeks, included participants with a normal body mass index, and had a mean age below 50 years.
Conclusion:
This systematic review and meta-analysis suggest that cranberry consumption was not effective in managing SBP and DBP.
Related Concept Videos
Factors affecting Blood pressure
Physiological Factors:
Disorders of the Autonomic Nervous System
Raynaud's disease, also known as Raynaud's phenomenon, is a...
Hypertension and Regulation of Blood Pressure
Antihypertensive Drugs: Action of β1 Blockers
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
Atherosclerosis III: Management
