Related Experiment Video
Updated: Apr 21, 2026
09:01
Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
Published on: May 22, 2020
3.7K
Inhomogeneous Strain-Modulated Phonon Scattering Sustains Hot Electrons for Enhanced Enzymatic Therapy
Sida Cao1, Yuanfei Yao2, Shuming Dong1
1Key Laboratory of Superlight Materials and Surface Technology, College of Materials Science and Chemical Engineering, Ministry of Education, Harbin Engineering University, Harbin, P. R. China.
Angewandte Chemie (International Ed. in English)
|April 20, 2026
Summary
Strain-engineered nanozymes (PWO) enhance tumor therapy by utilizing confined lattice heat and hot electrons to boost catalytic activity. This approach improves enzymatic therapy efficacy and induces tumor cell apoptosis.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Enzymatic therapy shows promise for cancer treatment.
- Enhancing nanozyme catalytic activity in tumor cells is a key challenge.
Purpose of the Study:
- To design strain-engineered nanozymes (PWO) for improved tumor therapy.
- To investigate the role of inhomogeneous lattice strain in nanozyme catalysis.
Main Methods:
- Fabrication of platinum (Pt) nanodots on tungsten oxide (WOx) nanoribbons to create PWO.
- Analysis of phonon spectrums to understand strain effects on electron-phonon interactions.
- Evaluation of photothermal conversion efficiency and enzymatic catalytic activity.
Main Results:
- Inhomogeneous strain confined lattice heat, reducing WO(x) photothermal conversion efficiency.
- Hot electrons, influenced by confined heat and potential difference, reduced enzymatic reaction activation energy by 51.30%.
- PWO induced tumor cell apoptosis by damaging mitochondria and the cytoskeleton.
Conclusions:
- Strain engineering effectively regulates hot-electron dynamics in nanozymes.
- This provides a novel strategy for enhancing nanozyme catalysis in enzymatic therapy.
- PWO demonstrates potential for effective tumor treatment via apoptosis induction.
Related Concept Videos
01:29Diversity of Archaea IV
632
Hyperthermophilic archaea are a group of extremophiles thriving at temperatures above 80°C, often in hydrothermal vents and volcanic soils where conditions surpass the boiling point of water. At such temperatures, proteins, membranes, and DNA in most organisms degrade, but hyperthermophiles have evolved remarkable adaptations to maintain stability and function.Unique Cellular FeaturesHyperthermophilic membranes are composed of a monolayer of biphytanyl tetraether lipids, which resist...
632
01:27Diversity of Archaea III
472
Crenarchaeota, a prominent phylum of Archaea, is remarkable for its ability to thrive in extreme environments characterized by high temperatures and acidity. These microorganisms inhabit sulfuric hot springs, volcanic systems, and submarine hydrothermal vents, where temperatures often exceed 100°C. The unique adaptations of Crenarchaeota not only allow survival under such extreme conditions but also provide insights into the mechanisms of life in primordial Earth-like...
472
01:19Thermal Strain
3.2K
Thermal strain is a concept that arises when we consider how temperature changes affect structures. Unlike the conventional assumption that structures remain constant under load, real-world scenarios often involve temperature fluctuations that can significantly impact these structures. Consider a homogeneous rod with a uniform cross-section resting freely on a flat horizontal surface. If the rod's temperature increases, the rod elongates. This elongation is proportional to the temperature...
3.2K
01:15Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)
1.2K
Insensitive Nuclei Enhanced by Polarization Transfer (INEPT) is an advanced Nuclear Magnetic Resonance (NMR) technique specifically designed to detect and enhance the signals of low-abundance nuclei, such as carbon-13 and nitrogen-15, in small molecules. The fundamental principle behind INEPT is the transfer of polarization from a more abundant and highly polarizable nucleus, typically hydrogen-1, to the low-abundance nucleus of interest. This process effectively boosts the NMR signal of the...
1.2K
01:18Enthalpy within the Cell
8.0K
Enthalpy (H) is used to describe the thermodynamics of chemical and physical processes. Enthalpy is defined as the sum of a system's internal energy (U) and the mathematical product of its pressure (P) and volume (V):
H = U + PV
Enthalpy is also a state function. Enthalpy values for specific substances cannot be measured directly; only enthalpy changes for chemical or physical processes can be determined. For processes that take place at constant pressure (a common condition for many...
H = U + PV
Enthalpy is also a state function. Enthalpy values for specific substances cannot be measured directly; only enthalpy changes for chemical or physical processes can be determined. For processes that take place at constant pressure (a common condition for many...
8.0K