Related Experiment Video

Updated: Apr 21, 2026

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.7K

The Quartet of Core Oncogenic Drivers in Neuroendocrine Prostate Cancer: Multi-Omics Dataset Integration to Forge a

Youzhi Wang1, Ning Wu2, Junbo Li3

  • 1Department of Urology, Peking University Third Hospital, Beijing, 100191, China.

International Journal of Biological Sciences
|April 20, 2026
PubMed

Insights

Neuroendocrine prostate cancer (NEPC) arises from advanced prostate cancer (PC) despite anti-androgen therapies. This review explores cancer stem cells, EMT, and autophagy roles in NEPC development and potential therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Prostate cancer (PC) is a leading cause of cancer death in men.
  • Advanced PC treatments like androgen deprivation therapy (ADT) can lead to castration-resistant (CRPC) and neuroendocrine (NEPC) forms.
  • The mechanisms driving PC progression to NEPC remain under investigation.

Purpose of the Study:

  • To comprehensively review cellular and molecular mechanisms of NEPC development.
  • To focus on the roles of cancer stem cells (CSCs), epithelial-mesenchymal transition (EMT), and autophagy in NEPC pathogenesis.
  • To explore therapeutic strategies targeting these pathways for advanced PC.

Main Methods:

  • Literature review integrating clinical trials, pre-clinical models, and molecular research.
  • Analysis of cellular mechanisms including CSCs, EMT, and autophagy.
  • Evaluation of potential therapeutic interventions targeting identified pathways.

Main Results:

  • NEPC development is linked to complex molecular changes following ADT.
  • CSCs, EMT, and autophagy are implicated as key drivers in NEPC progression.
  • Targeting these mechanisms shows promise for overcoming treatment resistance.

Conclusions:

  • Understanding NEPC pathogenesis is crucial for improving outcomes in advanced prostate cancer.
  • Targeting CSCs, EMT, and autophagy offers potential therapeutic avenues.
  • Further research integrating clinical and molecular data is needed to refine treatment strategies.
Keywords:
CSCsEMTNEPCPCautophagylineage plasticity

More Related Videos

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

7.3K
Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking07:34

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

1.4K

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.8K
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

2.6K
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
8.0K
Tumor Progression02:07

Tumor Progression

3.7K
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
10.3K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
12.3K